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1

Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis

Tsuchiya, Haruka, Ota, Mineto, Sumitomo, Shuji, Ishigaki, Kazuyoshi, Suzuki, Akari, Sakata, Toyonori, Tsuchida, Yumi, Inui, Hiroshi, Hirose, Jun, Kochi, Yuta, Kadono, Yuho, Shirahige, Katsuhiko, Tanak

Journal:

Annals of the Rheumatic Diseases

Year:

2020

File:

PDF, 5.18 MB

2020

2

A new subtilisin family: nucleotide and deduced amino acid sequences of new high-molecular-mass alkaline proteases fromBacillusspp.

Mitsuyoshi Okuda, Nobuyuki Sumitomo, Yasushi Takimura, Akinori Ogawa, Katsuhisa Saeki, Shuji Kawai, Tohru Kobayashi, Susumu Ito

Journal:

Year:

2004

Language:

english

File:

PDF, 538 KB

english, 2004

3

Epiphrenic diverticulum composed of airway components attributed to a bronchopulmonary-foregut malformation: Report of a case

Junichi Yoshida, Shinichi Ikeda, Shuji Mizumachi, Kenzo Sumitomo, Toshiro Iwai, Kenichi Matsuo, Akira Tanimura

Journal:

Year:

1999

Language:

english

File:

PDF, 121 KB

english, 1999

4

Site-directed mutagenesis of the putative active site of endoglucanase K from Bacillus sp. KSM-330

Katsuya Ozaki, Nobuyuki Sumitomo, Yasuhiro Hayashi, Shuji Kawai, Susumu Ito

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1994

Language:

english

File:

PDF, 519 KB

english, 1994

5

Nucleotide and deduced amino acid sequences of a high-molecular-mass subtilisin from an alkaliphilic Bacillus isolate

Akinori Ogawa, Nobuyuki Sumitomo, Mitsuyoshi Okuda, Katsuhisa Saeki, Shuji Kawai, Tohru Kobayashi, Susumu Ito

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2003

Language:

english

File:

PDF, 736 KB

english, 2003

6

Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4 + T cells

Iwasaki, Yukiko, Fujio, Keishi, Okamura, Tomohisa, Yanai, Atsushi, Sumitomo, Shuji, Shoda, Hirofumi, Tamura, Tomohiko, Yoshida, Hiroki, Charnay, Patrick, Yamamoto, Kazuhiko

Journal:

European Journal of Immunology

Year:

2013

Language:

english

File:

PDF, 959 KB

english, 2013

7

Synovial Bursa Protruding Through the Triceps Brachii Muscle

Shoda, Hirofumi, Sumitomo, Shuji, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Arthritis & Rheumatology

Year:

2014

Language:

english

File:

PDF, 72 KB

english, 2014

8

Construction, Purification, and Properties of a Truncated Alkaline Endoglucanase from Bacillus sp. KSM-635

Ozaki, Katsuya, Hayashi, Yasuhiro, Sumitomo, Nobuyuki, Kawai, Shuji, Ito, Susumu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1995

Language:

english

File:

PDF, 984 KB

english, 1995

9

Application of the Upstream Region of a Bacillus Endoglucanase Gene to High-level Expression of Foreign Genes in Bacillus subtilis

Sumitomo, Nobuyuki, Ozaki, Katsuya, Hitomi, Jun, Kawaminami, Shunro, Kobayashi, Tohru, Kawai, Shuji, Ito, Susumu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1995

Language:

english

File:

PDF, 704 KB

english, 1995

10

Egr2 and Egr3 are the unique regulators for systemic autoimmunity

Sumitomo, Shuji, Fujio, Keishi, Okamura, Tomohisa, Yamamoto, Kazuhiko

Journal:

Year:

2013

Language:

english

File:

PDF, 350 KB

english, 2013

11

TGF-β3-expressing CD4+CD25−LAG3+ regulatory T cells control humoral immune responses

Okamura, Tomohisa, Sumitomo, Shuji, Morita, Kaoru, Iwasaki, Yukiko, Inoue, Mariko, Nakachi, Shinichiro, Komai, Toshihiko, Shoda, Hirofumi, Miyazaki, Jun-ichi, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 2.09 MB

english, 2015

12

A case of refractory polyarteritis nodosa successfully treated with rituximab

Seri, Yu, Shoda, Hirofumi, Hanata, Norio, Nagafuchi, Yasuo, Sumitomo, Shuji, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Modern Rheumatology

Year:

2015

Language:

english

File:

PDF, 540 KB

english, 2015

13

Characteristics of granulomatosis with polyangiitis patients in Japan

Tsuchida, Yumi, Shibuya, Mihoko, Shoda, Hirofumi, Sumitomo, Shuji, Kubo, Kanae, Setoguchi, Keigo, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Modern Rheumatology

Year:

2015

Language:

english

File:

PDF, 252 KB

english, 2015

14

Autoantigen BiP-Derived HLA-DR4 Epitopes Differentially Recognized by Effector and Regulatory T Cells in Rheumatoid Arthritis

Shoda, Hirofumi, Fujio, Keishi, Sakurai, Keiichi, Ishigaki, Kazuyoshi, Nagafuchi, Yasuo, Shibuya, Mihoko, Sumitomo, Shuji, Okamura, Tomohisa, Yamamoto, Kazuhiko

Journal:

Arthritis & Rheumatology

Year:

2015

Language:

english

File:

PDF, 508 KB

english, 2015

15

Nucleotide Sequence of the Gene for an Alkaline Endoglucanase from an Alkalophilic Bacillus and Its Expression in Escherichia coli and Bacillus subtilis

Sumitomo, Nobuyuki, Ozaki, Katsuya, Kawai, Shuji, Ito, Susumu

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1992

Language:

english

File:

PDF, 1.27 MB

english, 1992

16

Therapeutic potential of regulatory cytokines that target B cells

Fujio, Keishi, Okamura, Tomohisa, Sumitomo, , Shuji, Yamamoto, Kazuhiko

Journal:

International Immunology

Year:

2015

Language:

english

File:

PDF, 316 KB

english, 2015

17

Efficacy of intensive immunosuppression in exacerbated rheumatoid arthritis-associated interstitial lung disease

Ota, Mineto, Iwasaki, Yukiko, Harada, Hiroaki, Sasaki, Oh, Nagafuchi, Yasuo, Nakachi, Shinichiro, Sumitomo, Shuji, Shoda, Hirofumi, Tohma, Shigeto, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Modern Rheumatology

Year:

2016

Language:

english

File:

PDF, 606 KB

english, 2016

18

A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity

Shibuya, Mihoko, Fujio, Keishi, Shoda, Hirofumi, Okamura, Tomohisa, Okamoto, Akiko, Sumitomo, Shuji, Yamamoto, Kazuhiko

Journal:

European Journal of Immunology

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

19

Identification of tonsillar CD4+CD25−LAG3+ T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue

Sumitomo, Shuji, Nakachi, Shinichiro, Okamura, Tomohisa, Tsuchida, Yumi, Kato, Rika, Shoda, Hirofumi, Furukawa, Asayo, Kitahara, Nobuo, Kondo, Kenji, Yamasoba, Tatsuya, Yamamoto, Kazuhiko, Fujio, Keis

Journal:

Journal of Autoimmunity

Year:

2016

Language:

english

File:

PDF, 2.87 MB

english, 2016

20

Macrophage activation syndrome associated with tocilizumab treatment in adult-onset Still’s disease

Tsuchida, Yumi, Sumitomo, Shuji, Shoda, Hirofumi, Kubo, Kanae, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Modern Rheumatology

Year:

2016

Language:

english

File:

PDF, 442 KB

english, 2016

21

Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity

Morita, Kaoru, Okamura, Tomohisa, Sumitomo, Shuji, Iwasaki, Yukiko, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Year:

2016

Language:

english

File:

PDF, 85 KB

english, 2016

22

Improvement of Cardiac Diastolic Function and Prognosis After Autologous Peripheral Blood Stem Cell Transplantation in AL Cardiac Amyloidosis

Yagi, Shusuke, Akaike, Masashi, Ozaki, Shuji, Moriya, Chikako, Takeuchi, Kyoko, Hara, Tomoko, Fujimura, Mitsunori, Sumitomo, Yuka, Iwase, Takashi, Ikeda, Yasumasa, Aihara, Ken-ichi, Kimura, Takehiko,

Journal:

Internal Medicine

Year:

2007

Language:

english

File:

PDF, 1.63 MB

english, 2007

23

Immune responses to Mycobacterial heat shock protein 70 accompany self-reactivity to human BiP in rheumatoid arthritis

Shoda, Hirofumi, Hanata, Norio, Sumitomo, Shuji, Okamura, Tomohisa, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.45 MB

english, 2016

24

Inflammatory Pseudotumors in Multiple Organs Associated with Elevated Serum IgG4 Level: Recovery by Only a Small Replacement Dose of Steroid

Tsuboi, Hiroto, Inokuma, Shigeko, Setoguchi, Keigo, Shuji, Sumitomo, Hagino, Noboru, Tanaka, Yoshiaki, Yoshida, Nozomi, Hishima, Tsunekazu, Kamisawa, Terumi

Journal:

Internal Medicine

Year:

2008

Language:

english

File:

PDF, 386 KB

english, 2008

25

Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production

Morita, Kaoru, Okamura, Tomohisa, Inoue, Mariko, Komai, Toshihiko, Teruya, Shuzo, Iwasaki, Yukiko, Sumitomo, Shuji, Shoda, Hirofumi, Yamamoto, Kazuhiko, Fujio, Keishi

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.84 MB

english, 2016

26

Cell Proliferation Activity in Duct-Ligated Submandibular Gland.

Sumitomo, Shinichiro, Kunikata-Sumitomo, Mayuko, Hashimoto, Junji, Namba, Miyako, Shrestha, Prashanta, Kurenuma, Shuji, Jayasinghe, Neeta, Mori, Masahiko

Journal:

Acta Histochemica et Cytochemica

Year:

1995

Language:

english

File:

PDF, 15.37 MB

english, 1995

27

Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4+ T cells, and disease activity

Nagafuchi, Yasuo, Shoda, Hirofumi, Sumitomo, Shuji, Nakachi, Shinichiro, Kato, Rika, Tsuchida, Yumi, Tsuchiya, Haruka, Sakurai, Keiichi, Hanata, Norio, Tateishi, Shoko, Kanda, Hiroko, Ishigaki, Kazuyo

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.44 MB

english, 2016

28

Interleukin-10-producing LAG3+regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis

Nakachi, Shinichiro, Sumitomo, Shuji, Tsuchida, Yumi, Tsuchiya, Haruka, Kono, Masanori, Kato, Rika, Sakurai, Keiichi, Hanata, Norio, Nagafuchi, Yasuo, Tateishi, Shoko, Kanda, Hiroko, Okamura, Tomohisa

Journal:

Arthritis Research & Therapy

Year:

2017

Language:

english

File:

PDF, 1.00 MB

english, 2017

29

Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis

Ishigaki, Kazuyoshi, Kochi, Yuta, Suzuki, Akari, Tsuchida, Yumi, Tsuchiya, Haruka, Sumitomo, Shuji, Yamaguchi, Kensuke, Nagafuchi, Yasuo, Nakachi, Shinichiro, Kato, Rika, Sakurai, Keiichi, Shoda, Hiro

Journal:

Nature Genetics

Year:

2017

Language:

english

File:

PDF, 1.62 MB

english, 2017

30

Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis

Shoda, Hirofumi, Nagafuchi, Yasuo, Tsuchida, Yumi, Sakurai, Keiichi, Sumitomo, Shuji, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Arthritis Research & Therapy

Year:

2017

Language:

english

File:

PDF, 627 KB

english, 2017

31

Polymorphic lymphoproliferative disorders in patients with rheumatoid arthritis are associated with a better clinical outcome

Tsukui, Daisuke, Kanda, Hiroko, Shinozaki-Ushiku, Aya, Tateishi, Shoko, Takeshima, Yusuke, Nagafuchi, Yasuo, Sasaki, Oh, Iwasaki, Yukiko, Harada, Hiroaki, Shibuya, Mihoko, Sumitomo, Shuji, Shoda, Hiro

Journal:

Modern Rheumatology

Year:

2017

Language:

english

File:

PDF, 849 KB

english, 2017

32

A gene module associated with dysregulated TCR signaling pathways in CD4 + T cell subsets in rheumatoid arthritis

Sumitomo, Shuji, Nagafuchi, Yasuo, Tsuchida, Yumi, Tsuchiya, Haruka, Ota, Mineto, Ishigaki, Kazuyoshi, Nakachi, Shinichiro, Kato, Rika, Sakurai, Keiichi, Hanata, Norio, Tateishi, Shoko, Kanda, Hiroko,

Journal:

Journal of Autoimmunity

Year:

2017

Language:

english

File:

PDF, 2.32 MB

english, 2017

33

HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis

Sakurai, Keiichi, Ishigaki, Kazuyoshi, Shoda, Hirofumi, Nagafuchi, Yasuo, Tsuchida, Yumi, Sumitomo, Shuji, Kanda, Hiroko, Suzuki, Akari, Kochi, Yuta, Yamamoto, Kazuhiko, Fujio, Keishi

Journal:

The Journal of Rheumatology

Year:

2018

Language:

english

File:

PDF, 10.86 MB

english, 2018

34

Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells

Teruya, Shuzo, Okamura, Tomohisa, Komai, Toshihiko, Inoue, Mariko, Iwasaki, Yukiko, Sumitomo, Shuji, Shoda, Hirofumi, Yamamoto, Kazuhiko, Fujio, Keishi

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 3.00 MB

english, 2018

35

Rhabdomyolysis Induced by Isoniazid in a Patient with Rheumatoid Arthritis and End-stage Renal Disease: A Case Report and Review of the Literature

Komai, Toshihiko, Sumitomo, Shuji, Teruya, Shuzo, Fujio, Keishi

Journal:

Internal Medicine

Year:

2018

Language:

english

File:

PDF, 742 KB

english, 2018

36

Reduction of CD83 expression on B Cells and the genetic basis for rheumatoid arthritis: Comment on the article by Thalayasingam et al

Tsuchida, Yumi, Sumitomo, Shuji, Ishigaki, Kazuyoshi, Ota, Mineto, Tsuchiya, Haruka, Yamaguchi, Kensuke, Nagafuchi, Yasuo, Shoda, Hirofumi, Suzuki, Akari, Kochi, Yuta, Fujio, Keishi, Yamamoto, Kazuhik

Journal:

Arthritis & Rheumatology

Year:

2018

Language:

english

File:

PDF, 200 KB

english, 2018

37

Regulatory T Cell-Mediated Control of Autoantibody-Induced Inflammation

Fujio, Keishi, Okamura, Tomohisa, Sumitomo, Shuji, Yamamoto, Kazuhiko

Journal:

Frontiers in Immunology

Year:

2012

Language:

english

File:

PDF, 599 KB

english, 2012

38

Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals

Komai, Toshihiko, Inoue, Mariko, Okamura, Tomohisa, Morita, Kaoru, Iwasaki, Yukiko, Sumitomo, Shuji, Shoda, Hirofumi, Yamamoto, Kazuhiko, Fujio, Keishi

Journal:

Frontiers in Immunology

Year:

2018

Language:

english

File:

PDF, 5.44 MB

english, 2018

39

Transcriptome analysis of peripheral blood from patients with rheumatoid arthritis: a systematic review

Sumitomo, Shuji, Nagafuchi, Yasuo, Tsuchida, Yumi, Tsuchiya, Haruka, Ota, Mineto, Ishigaki, Kazuyoshi, Suzuki, Akari, Kochi, Yuta, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

Inflammation and Regeneration

Year:

2018

Language:

english

File:

PDF, 574 KB

english, 2018

40

The functions of CD4+CD25-LAG3+ regulatory T cells and Egr2 in the regulation of autoimmunity

FUJIO, Keishi, OKAMURA, Tomohisa, SUMITOMO, Shuji, YAMAMOTO, Kazuhiko

Journal:

Japanese Journal of Clinical Immunology

Year:

2014

File:

PDF, 816 KB

2014

41

CD4+CD25âLAG-3+ T cells in mouse and human

SUMITOMO, Shuji, YAMAMOTO, Kazuhiko

Journal:

Japanese Journal of Clinical Immunology

Year:

2010

File:

PDF, 312 KB

2010

42

Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis

Kobayashi, Satomi, Nagafuchi, Yasuo, Okubo, Mai, Sugimori, Yusuke, Shirai, Harumi, Hatano, Hiroaki, Junko, Maeda, Yanaoka, Haruyuki, Takeshima, Yusuke, Ota, Mineto, Iwasaki, Yukiko, Sumitomo, Shuji, O

Journal:

Journal of Autoimmunity

Year:

2020

File:

PDF, 3.44 MB

2020

43

Massive calcinosis cutis associated with primary SjÃ¶grenâs syndrome

Tsuchida, Yumi, Sumitomo, Shuji, Fujio, Keishi, Yamamoto, Kazuhiko

Journal:

BMJ Case Reports

Year:

2016

File:

PDF, 294 KB

2016